In recent years, "weight-loss pens" have become a widely discussed term in Thailand, particularly referring to a group of drugs... GLP-1 receptor agonist It has gained more attention among working people aged 30–45, with many saying that...
"It's true that you eat less after getting the injection."
"Losing weight faster than before."
"You don't have to push yourself as hard as before."
Scientifically, there is evidence supporting its effectiveness in reducing weight in individuals who meet the criteria for obesity. However, from a preventive medicine perspective, a deeper question arises:
Is weight gain solely due to increased appetite, or is it a sign of a long-standing metabolic imbalance?
GLP-1 is a hormone produced in the intestines that helps regulate blood sugar levels and satiety. Medications in this group will...
Information from Mayo Clinic The mechanism of semaglutide is clearly explained as acting through this system.
But it's important to understand that suppressing appetite alone doesn't address the root cause. insulin resistanceCortisol imbalance or muscle mass loss.
“Test hormones related to metabolism and stress.”
The use of this medication is not for "losing weight quickly," but is part of a plan to treat obesity as a chronic disease.
In Asian populations, metabolic risk develops faster, and several approaches are used.
However, the decision to use medication should not be based solely on BMI, because BMI does not reflect "how the metabolism works." In some people, their BMI may be near normal, but they may have insulin resistance, high levels of visceral fat, thyroid hormone imbalances, or unnoticed muscle mass loss.
Therefore, assessing metabolic factors may include fasting insulin levels, an in-depth lipid profile, a thyroid panel, and body composition (fat vs. lean mass) to understand the root cause before choosing any specific tools.
“A more in-depth lipid profile test than standard lipid readings.”
Your metabolism doesn't break down in a day. Gradual weight gain is often the result of small changes accumulating over a period of time.
Many people have a health checkup and find their "normal blood sugar" levels, so they are relieved that they don't have any metabolic problems. However, in the early stages... insulin resistance Blood sugar levels may still be within the normal range because the body compensates by releasing more insulin. Insulin's function is to transport sugar into cells, but when cells respond less effectively, the body needs to release more.
Chronically high insulin levels don't just control blood sugar; they're also a "fat-storing hormone," particularly responsible for visceral fat. This is why some people report "eating the same amount, but getting a bigger belly." From a preventive medicine perspective, looking only at FBS (fasting blood sugar) is insufficient. Levels of fasting insulin and metabolic elasticity may provide a clearer picture.
When we stay up late, work hard, and experience continuous stress, our bodies enter "survival mode."
Chronically high cortisol levels result in...
Even though you don't eat more, your body allocates energy differently.
After age 30, muscle mass naturally decreases with the absence of resistance training. As muscle mass decreases... Basal Metabolic Rate (BMR) It will decrease accordingly. The result is:
This is why some people feel that "the older you get, the harder it is to lose weight."
"Assess body composition (fat vs. muscle)"
What is rarely discussed is that rapid weight loss, without proper nutrition and muscle management, can lead to a loss of some lean mass. In anti-aging medicine, preserving muscle is very important because muscle is...
Therefore, the goal shouldn't just be "weight loss," but rather "fat loss while maintaining muscle mass."
Nausea, feeling full quickly, and bloating are results of slowed gastric motility. In some individuals, these symptoms may also occur.
Instead of viewing it simply as a “side effect,” we might see it as a sign that the body is adjusting to rapid changes.
Some people reported that after using the medication...
Weight loss isn't just about biochemistry; it's about your "relationship with food" and your "self." For some, weight loss can change their self-image, but for others, it can create new pressure. This is why a holistic approach is important.
These medications are quite expensive and often require continuous use. The key question is:
In some cases, a doctor may consider an evaluation.
Because "normal" baseline test results don't necessarily mean a balanced metabolism, at W9 we often start by understanding each individual's body before choosing any diagnostic tools.
“A comprehensive test to assess insulin resistance and body balance.”
Should not be used in individuals who:
Weight-loss pens are evidence-based tools, and in eligible individuals, they may be part of a suitable care plan. However, this powerful tool should be used based on an understanding of one's own metabolism. Sometimes, slowing down to understand the root causes can lead to more sustainable long-term results, because ultimately, good health isn't measured solely by weight, but by the flexibility and balance of the entire system.
1. How long do I need to take the medication?
Several studies followed patients for 1–2 years and found that some weight may return if the medication was stopped.
2. Will I experience a yo-yo effect after stopping the medication?
It is possible, if the basic metabolic system is not adjusted.
3. Is hair loss real?
This may be due to rapid weight loss rather than a direct effect of the medication.
4. Is it safe to use in people with a BMI below 27?
It can be used, but requires medical consideration based on other indications.
5. Can it be used in conjunction with exercise?
Exercise should be included to maintain muscle mass.
6. Does it affect my mood?
There have been some reported cases, but there is no conclusive research evidence.
7. Is it suitable for everyone?
Not suitable for individuals with FDA contraindications.
8. What tests should be done before starting?
Fasting insulin, thyroid panel, body composition, etc.
9. Are weight-loss pens a long-term solution?
It's one tool, but adjusting the metabolic system is more important.
If you experience easy weight gain and fatigue despite normal basic test results, an in-depth metabolic assessment before deciding to use a weight-loss pen may help you better understand your body.
Praram 9 Hospital (3rd floor, Building A)
Written and compiled by
Dr. Araya Damnernsawad (Dr. Am)
Anti-aging and preventative medicine physician
W9 Wellness Center
References
Eat clean, exercise, but don't lose any weight! Are you experiencing this kind of problem? Whatever one says is good, we try it all.
Insomnia ..is another problem that can happen to anyone, any gender, any age. The average person's insomnia symptoms are 1-2.
Hormonal imbalance Because the lifestyle of the new generation, in addition to having Work-Life Balance, creates a balance between work life. and personal life To increase work efficiency
