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Vitamin D

Vitamin D and the immune system

Vitamin D It's not just about bones and teeth. but boosts the immune system (immunity) of the body

From the introduction from the previous article that Vitamin D is a hormone. that does not just control Calcium and bone homeostasis only. Today we will get to know the role of Vitamin D in the body's immune system (Vitamin D & Immunity).

What does vitamin D have to do with immunity?

Vitamin D has a complex mechanism of action. Various mechanisms in the normal immune system By helping to create and control the function of all types of white blood cells in the immune system which is related to allergies Autoimmune diseases and cancer, we have known for a long time from large studies that Vitamin D deficiency increases the risk of death from all causes and death from infectious diseases in“General people”too (1)

Vitamin D & Autoimmunity

Vitamin D deficiency Associated with autoimmune diseases in various systems such as rheumatoid arthritis and SLE. Vitamin D supplementation In patients with autoimmune diseases with low vitamin D levels It has been found to help control disease better. Vitamin D travels to bind to receptors (Vitamin D receptor) on various types of white blood cells (B cells, T cells, and APCs) to inhibit the production of inflammatory substances. (pro-inflammatory cytokines) produced by white blood cells The workplace is distorted. It also stimulates the creation of regulatory T-cells, helping to control behavior (inhibit Th17-response) to prevent white blood cells from becoming unruly. It also hurts the normal tissues of the body in another way.

Vitamin D Immune

Vitamin D & Infection

In addition, people with low levels of vitamin D are more likely toGet infected more easily than other peopleAlso (2) Especially respiratory infections, the flu, bronchitis, pneumonia, and tuberculosis. Vitamin D stimulates the production of and stimulate the work of macrophage white blood cells to capture and eat germs (phagocytosis) and also stimulates the production of germicidal substances (Antimicrobial peptides) which can inhibit both bacteria, viruses and fungi. (3)

In 2010, a trial of 167 Japanese schoolchildren with 1,200 IU daily vitamin D3 supplementation was conducted without regard to vitamin D levels. It was found that vitamin D supplementation Can reduce the incidence of seasonal influenza A by almost double. In the group of children who received vitamin D supplementation (4)

Vitamin D & COVID-19

From all the information mentioned above. As a result, there has been a lot of research on vitamin D and COVID-19 in 2020, confirming the importance of vitamin D. with protection against infection (prevention) helps fight viruses (antiviral activity), reduces disease severity (severity) and reduces death rate (mortality) (8In patients with severe symptoms It is well known that part will die from control “Cytokine Storm” (Substances resulting from the fight between white blood cells and viruses) Cytokines therefore destroy the lung tissue. which vitamin D has a duty to control Prevent excessive production and secretion of these Cytokines. The research therefore concludes that People with low vitamin D Will have a higher chance of death than people with normal vitamin D levels. 15.6% (9) and vitamin D supplementation in the general population Helpful in preventing COVID-19 infection. (10,11)

Read more articles about vitamin D.

References:

  1. VitaminD levels and the risk of mortality in the general population, Arch Intern Med. (2008)
  2. VitaminD and Immune System, Journal of Investigative Medicine (2011)
  3. The impact of vitaminD on infectious disease, The American journal of the medical sciences (2015)
  4. Randomized trial of vitaminD supplementation to prevent seasonal influenza A in schoolchildren, The American Journal of Clinical Nutrition (2010)
  5. VitaminD and Influenza, Advances in Nutrition (2012)
  6. The Effects of VitaminD on Immune System (2015)
  7. VitaminD deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and Meta-analysis, Critical Care (2014)
  8. Does VitaminD status impact mortality from SARS-CoV-2 infection? Med Drug Discov. (2020)
  9. The Possible Role of VitaminD in suppressing Cytokine Storm and associated mortality in COVID-19 patients, Boston Medical Center (2020)
  10. Evidence that VitaminD supplementation could reduce risk of Influenza and COVID-19 infection and Death, Nutrients (2020)
  11. The Role of VitaminD in the prevention of coronavirus disease 2019 infection and mortality, The Queen Elizabeth Hospital Foundation Trust, King's Lynn (2020)

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